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. 2022 Jun 7;12:9400. doi: 10.1038/s41598-022-13488-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The expression profile of genes encoding ECS transport and degrading proteins. Transcription expression that showed a significant difference at any stage in the menstrual cycle were plotted against cycle stage. (A) For the transporting proteins moderate expression was observed for FABP5 and FABP3 that was significantly increased across the menstrual cycle. (B) ECS degrading enzymes had a moderate to low expression that were most commonly altered between the menstrual and early proliferative stage, or during the period from the late proliferative to mid secretory stage. Two genes ABHD12 and NAAA showed a consistent increase over the proliferative stage, after which there was decrease in expression. M = Menstrual, EP = Early proliferative, MP = Mid proliferative, LP = Late proliferative, ES = Early secretory, MS = Mid secretory, LS = Late secretory.