Table 2.
Overlap of significant findings from previous studies of differential DNAm by sex with full term placenta results. Results from previous studies restricted to autosomes.
| Study | Year | Tissue | # Significant autosomal CpG sites differential by sex | # Significant sites included in post QC, full term placenta dataset (%)a | Overlap with placenta full term results (%)b |
|---|---|---|---|---|---|
| Price et al | 2013 | Peripheral blood, adult | 45 | 40 (88.89%) | 13 (0.25%) |
| Hall et al | 2014 | Pancreatic islets | 470 | 339 (72.13%) | 55 (1.06%) |
| Xu et al | 2014 | Prefrontal cortex | 13,560 | 13,554 (99.96%) | 331 (6.35%) |
| Inoshita et al | 2015 | Peripheral leukocytes | 292 | 292 (100%) | 103 (1.98%) |
| Singmann et al | 2015 | Peripheral blood | 11,010 | 11,008 (99.98%) | 530 (10.2%) |
| Spiers et al | 2015 | Fetal cortex | 521 | 521 (100%) | 103 (1.98%) |
| Yousefi et al | 2015 | Cord blood | 3031 | 3031 (100%) | 318 (6.10%) |
| Martin et al | 2017 | Placenta | 15 | 1 (6.7%) | 1 (0.02%) |
| Suderman et al | 2017 | Cord blood | 11,965 | 11,961 (99.97%) | 274 (5.26%) |
| Peripheral blood, 7 years | 13,672 | 13,669 (99.98%) | 310 (5.95%) | ||
| Peripheral blood, 15–17 years | 12,215 | 12,214 (99.99%) | 291 (5.58%) | ||
| Xia et al | 2019 | Prefrontal cortex, Bulk Brain | 15,417 | 15,048 (97.61%) | 439 (8.42%) |
| Inkster et al | 2021 | Placenta | 166 | 166 (100%) | 146 (2.8%) |
aPercentage indicates proportion of significant sites from specified study included in placenta full term, post QC dataset.
bPercentage indicates proportion of significant sites from specified study found in significant findings from full term analysis (p < 1E−8, n = 5212).