Table 4.

Persistence of genome-wide significant differentially methylated regions from full term analysis across the gestational period.

chr	start	end	p. value	fwer	p. value area	fwer area	MD, full term	Nearest gene (location)	MD, trimester1	MD, trimester 2	MD, trimester 3	Contains cell type discriminating probes?
chr19	52,074,293	52,074,501	0	0	0	0	0.17	ZNF175 (promoter)	0.24	0.0831	0.11	No
chr5	150,284,416	150,284,796	0	0	0	0	0.172	ZNF300 (promoter)	0.21	0.212	0.159	Yes
chr5	126,408,756	126,409,553	0	0	0	0	− 0.0737	C5orf63 (promoter)	− 0.00439	− 0.101	− 0.101	Yes
chr11	2,906,285	2,907,127	0	0	1.83E−06	0.007	0.0243	CDKN1C (gene body)	0.0325	0.0159	0.0295	No
chr7	86,974,674	86,975,244	2.61E−07	0.001	3.66E−06	0.014	− 0.0522	CROT (promoter)	− 0.0514	− 0.0743	− 0.0761	Yes
chr7	27,169,674	27,171,051	5.23E−07	0.002	1.05E−05	0.039	− 0.0372	HOXA4 (promoter)	− 0.0106	− 0.0035	0.00492	Yes
chr4	90,758,120	90,759,203	1.05E−06	0.004	1.73E−05	0.065	− 0.0393	SNCA (promoter)	− 0.0216	− 0.0138	− 0.00186	No
chr6	28,641,622	28,642,394	3.4E−06	0.013	1.83E−05	0.069	0.0329	ZBED9 (58 Kb downstream	0.0419	0.0692	0.0452	Yes
chr9	98,637,332	98,638,444	2.61E−07	0.001	2.25E−05	0.085	− 0.0561	ERCC6L2 (promoter)	− 0.0427	− 0.0143	− 0.0321	No

Statistics generated from bumphunter()⁶⁴ function in minfi package⁵⁷. Mean Difference (MD) values calculated as mean in male samples—mean in female samples. Final column indicates if DMR contained cell type distinguishing probe as identified by Yuan et al. in full term samples.