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Locus on chromosome 1q41. SNP rs67420025 shows a suggestive association to appendicitis in the Pan-UKBB cohort, and it is located in the promoter region of HLX and overlaps a transcription start site (TSS) in colon smooth muscle. The right panel shows a significant increase in HLX expression in the appendix of 9 appendicitis patients and 4 controls. The box at the bottom shows the function of HLX as reported in the literature and PathCards. SNP, single-nucleotide polymorphism.
