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. 2022 May 25;13:862742. doi: 10.3389/fimmu.2022.862742

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Copyright © 2022 Ricaño-Ponce, Peeters, Matzaraki, Houben, Achten, Cools, Netea, Gyssens and Kumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Locus on chromosome 8p32.1. The strongest association in this locus corresponds to SNP rs2686198 with a p-value of 8.48 × 10−7 in the Pan- UKBB cohort. There are multiple genes in the locus, but only cathepsin B (CTSB) is significantly overexpressed in the appendix of patients compared to individuals who were undergoing intra-abdominal surgery for a non-inflammatory condition, as depicted in the left panel. The risk allele of rs2686198*C is associated with higher expression of CTSB in sigmoid colon in healthy individuals. The left panel shows the function of CTSB according to Reactome. SNP, single-nucleotide polymorphism.