Figure 1.

Viability, proliferation and mitochondrial function of PCa cells treated with DCA. (A) Cell viability is shown for LNCaP and DU-145 PCa cells, as determined by MTS analysis, after 72 h in the presence of DCA (5 mM and 20 mM). (B) Cell viability is shown for LNCaP cells, as determined by MTS analysis, after 72 h in the presence of DCA (1 mM and 5 mM). (C) Cell growth is shown for LNCaP cells, as determined by Incucyte live-cell analysis, after 72 h in the presence of DCA (1 mM and 5 mM). (D) Mitochondrial respiration is shown for LNCaP cells, as determined by Seahorse extracellular flux analysis, after 48 h in the presence of DCA (1 mM and 5 mM). p value below 0.05 are indicated with *.