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. 2022 Apr 7;3(6):e408–e416. doi: 10.1016/S2666-5247(21)00308-6

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© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Combined effect of enteropathogen burden and gastrointestinal symptoms on C_max and AUC_0–24

C_max=peak drug concentration. AUC_0–24=total exposure area under the concentration curve over 24 hs (A) Percentage change in C_max per pathogen detected. (B) Percentage change in AUC_0–24 per pathogen detected. Log-C_max and log-AUC_0–24 were modelled as functions of enteropathogen burden and the presence of gastrointestinal symptoms. Estimates were back-transformed to calculate the relative change in C_max or AUC_0–24. Estimates were adjusted for mg/kg drug dose, age, sex, and body-mass index Z score. 95% CIs are shown and are truncated above 100%. Results from bivariable analysis without adjustment for covariates are available in appendix 2 pp 5–6.