TABLE 2.

Evolution of therapies across time.

	Time (months)
	0 (%)	6 (%)	12 (%)	18 (%)	24 (%)	30 (%)	p*
MRAs	50	41	37	34	31	30	<0.001
Statins	78	78	78	79	78	79	1.000
Beta-blockers	99	99	99	99	99	99	1.000
OACs	33	33	33	32	32	32	1.000
Antiplatelet therapy	57	57	57	58	58	56	1.000
Diuretics	100	90	86	82	79	78	<0.001
OADs**	100	92	83	79	72	65	<0.001
Insulin therapy**	30	27	24	21	18	13	<0.001
Sac/val Dose mg
100	62	20	20	19	19	19	<0.001
200	38	58	58	58	58	55
400		22	22	23	23	26

p*derived by Test di Cochran’ Q on listwise; derived by Friedman test for entresto doses. MRAs, mineralocorticoid receptor antagonists; OACs, oral anticoagulants; OADs, oral antidiabetic drugs; Sac/val, Sacubitril-Valsartan. **only on diabetic patients.

The percentage changes in drug classes taken by patients at baseline and during follow-up are shown in bold.