TABLE 1.
Predicted histone modifications associated with overexpressed genes in perivascular adipose tissue of small and large abdominal aortic aneurysms.
| Feature | Reference | Description | NES |
|---|---|---|---|
| Small AAA | |||
| E124-H3K27ac-broadpeak | ENCODE | H3K27ac in Monocytes-CD14+ RO01746 Primary Cells | 7.91 |
| ENCFF001TAS (E124) | ENCODE | H4K20me1 in ChIP-seq on human monocytes CD14+ | 6.47 |
| E127-H3K36me3-broadpeak | ENCODE | H3K36me3 in NHEK-Epidermal Keratinocyte Primary Cells | 6.17 |
| E039-H3K27ac-broadpeak | Roadmap | H3K27ac in Primary T helper naive cells from peripheral blood | 5.28 |
| E041-H3K36me3-broadpeak | Roadmap | H3K36me3 in Primary T helper cells PMA-I stimulated | 5.03 |
| E025-H3K36me3-broadpeak | Roadmap | H3K36me3 in Adipose-derived Mesenchymal Stem Cell cultured cells | 4.85 |
| ENCFF001TBR (E126) | ENCODE | H3K9ac in ChIP-seq on human NHDF-Ad | 4.79 |
| E124-H3K9ac-broadpeak | ENCODE | H3K9ac in Monocytes-CD14+ RO01746 Primary Cells | 4.58 |
| E126-H3K9ac-broadpeak | ENCODE | H3K9ac in NHDF-Ad Adult Dermal Fibroblast Primary Cells | 4.54 |
| E025-H3K9ac-broadpeak | Roadmap | H3K9ac in Adipose-derived Mesenchymal Stem Cell cultured cells | 4.52 |
| E119-H3K36me3-broadpeak | ENCODE | H3K36me3 in HMEC Mammary Epithelial Primary Cells | 4.33 |
| ENCFF001TAQ (E124) | ENCODE | H3K36me3 in ChIP-seq on human monocytes CD14+ | 4.31 |
| E124-H3K9ac | ENCODE | H3K9ac in Monocytes-CD14+ RO01746 Primary Cells | 4.27 |
| E034-H3K27ac-broadpeak | Roadmap | H3K27ac in Primary T cells from peripheral blood | 4.21 |
| E047-H3K9ac-broadpeak | Roadmap | H3K9ac in Primary T CD8+ naive cells from peripheral blood | 4.16 |
| E042-H3K36me3-broadpeak | Roadmap | H3K36me3 in Primary T helper 17 cells PMA-I stimulated | 4.05 |
| E124-H4K20me1-broadpeak | ENCODE | H4K20me1 in Monocytes-CD14+ RO01746 Primary Cells | 4.01 |
| ENCFF001TAL (E124) | ENCODE | H3K4me3 in ChIP-seq on human monocytes CD14 + | 4.00 |
| Large AAA | |||
| ENCFF001TAS (E124) | ENCODE | H4K20me1 in ChIP-seq on human monocytes CD14+ | 7.86 |
| E029-H3K36me3-broadpeak | Roadmap | H3K36me3 in Primary monocytes from peripheral blood | 7.52 |
| E124-H4K20me1-broadpeak | ENCODE | H4K20me1 in Monocytes-CD14+ RO01746 Primary Cells | 7.31 |
| E037-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary T helper memory cells from peripheral blood 2 | 6.69 |
| E124-H3K79me2-broadpeak | ENCODE | H3K79me2 in Monocytes-CD14+ RO01746 Primary Cells | 6.66 |
| E030-H3K4me1 | Roadmap | H3K4me1 in Primary neutrophils from peripheral blood | 6.53 |
| E124-H3K4me1-broadpeak | ENCODE | H3K4me1 in Monocytes-CD14 + RO01746 Primary Cells | 6.42 |
| E030-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary neutrophils from peripheral blood | 6.37 |
| E124-H3K4me3 | ENCODE | H3K4me3 in Monocytes-CD14 + RO01746 Primary Cells | 6.34 |
| E030-H3K36me3-broadpeak | Roadmap | H3K36me3 in Primary neutrophils from peripheral blood | 6.09 |
| E030-H3K4me3 | Roadmap | H3K4me3 in Primary neutrophils from peripheral blood | 6.03 |
| ENCFF001TAQ (E124) | ENCODE | H3K36me3 in ChIP-seq on human monocytes CD14+ | 5.97 |
| E040-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary T helper memory cells from peripheral blood 1 | 5.46 |
| E124-H3K27ac-broadpeak | ENCODE | H3K27ac in Monocytes-CD14 + RO01746 Primary Cells | 5.25 |
| E124-H3K79me2 | ENCODE | H3K79me2 in Monocytes-CD14+ RO01746 Primary Cells | 5.24 |
| E046-H3K36me3-broadpeak | Roadmap | H3K36me3 in primary Natural Killer cells from peripheral blood | 5.12 |
| E029-H3K27ac | Roadmap | H3K27ac in Primary monocytes from peripheral blood | 5.12 |
| E124-H3K9ac | ENCODE | H3K9ac in Monocytes-CD14+ RO01746 Primary Cells | 4.83 |
| E043-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary T helper cells from peripheral blood | 4.78 |
| E034-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary T cells from peripheral blood | 4.76 |
| ENCFF001TAR (E124) | ENCODE | H3K79me2 in ChIP-seq on human monocytes CD14+ | 4.64 |
| E124-H3K27ac | ENCODE | H3K27ac in Monocytes-CD14+ RO01746 Primary Cells | 4.62 |
| E030-H3K36me3 | Roadmap | H3K36me3 in Primary neutrophils from peripheral blood | 4.57 |
| E031-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary B cells from cord blood | 4.44 |
| E050-H3K4me1 | Roadmap | H3K4me1 in Primary hematopoietic stem cells G-CSF-mobilized female | 4.42 |
| E029-H3K4me1-broadpeak | Roadmap | H3K4me1 in Primary monocytes from peripheral blood | 4.38 |
| E031-H3K4me1 | Roadmap | H3K4me1 in Primary B cells from cord blood | 4.35 |
| E124-H3K4me1 | ENCODE | H3K4me1 in Monocytes-CD14+ RO01746 Primary Cells | 4.26 |
| E029-H3K36me3 | Roadmap | H3K36me3 in Primary monocytes from peripheral blood | 4.24 |
AAA, abdominal aortic aneurysm; ENCODE, Encyclopedia of DNA Elements; Roadmap, NIH Roadmap Epigenomics Consortium.
Histone mark signatures for acute (early) or trained immunity stimulation in small and large AAA, respectively, are highlighted in bold.