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. 2022 May 25;13:897487. doi: 10.3389/fimmu.2022.897487

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Copyright © 2022 Chen, Wu, Zhu, Chen, Xu, Tang, Jiao and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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METTL3 regulates endothelial function by targeting Trim59. (A) RT-qPCR analysis showing the levels of Trim59 expression after siRNA transfection. (B) Immunoblot showing Trim59 protein expression after siRNA transfection. (C) TEER was used to measure endothelial permeability in METTL3-overexpressing HULEC-5a cells with or without Trim59 siRNA. (D) Immunoblot showing the protein expression of VE-Cadherin and ICAM-1 in METTL3-overexpressing HULEC-5a cells with or without Trim59 siRNA. (E) RT-qPCR analysis showing inflammatory cytokine mRNA expression in METTL3-overexpressing HULEC-5a cells with or without Trim59 siRNA. All data are expressed as the mean ± SD of three independent experiment. **p < 0.01; ***p < 0.001; ****p < 0.0001.