Table 2.
Odds ratios (95% CIs) from logistic regression models for infertility treatment and children’s neurodevelopment at the age of 2 and 3.5 years (n=9655)
| N | 2 years | 3.5 years | |||||||||||||||
| n | % | Crude | Adjusted | n | % | Crude | Adjusted | ||||||||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | ||||||||||
| Lower | Upper | Lower | Upper | Lower | Upper | Lower | Upper | ||||||||||
| Total score | |||||||||||||||||
| Natural conception | 8895 | 1269 | 14.27 | ref | ref | 1149 | 12.92 | ref | ref | ||||||||
| OI/AIH | 273 | 58 | 21.25 | 1.62 | 1.21 | 2.18 | 1.36 | 1.00 | 1.85 | 40 | 14.65 | 1.16 | 0.82 | 1.63 | 1.13 | 0.79 | 1.61 |
| ART | 487 | 110 | 22.59 | 1.75 | 1.41 | 2.19 | 1.36 | 1.07 | 1.72 | 68 | 13.96 | 1.09 | 0.84 | 1.42 | 1.03 | 0.78 | 1.37 |
| Communication | |||||||||||||||||
| Natural conception | 8895 | 445 | 5.00 | ref | ref | 482 | 5.42 | ref | ref | ||||||||
| OI/AIH | 273 | 27 | 9.89 | 2.09 | 1.39 | 3.14 | 1.93 | 1.25 | 2.98 | 17 | 6.23 | 1.16 | 0.70 | 1.91 | 1.13 | 0.68 | 1.90 |
| ART | 487 | 27 | 5.54 | 1.12 | 0.75 | 1.66 | 0.95 | 0.62 | 1.45 | 29 | 5.95 | 1.11 | 0.75 | 1.63 | 1.04 | 0.69 | 1.56 |
| Gross motor | |||||||||||||||||
| Natural conception | 8895 | 483 | 5.43 | ref | ref | 367 | 4.13 | ref | ref | ||||||||
| OI/AIH | 273 | 20 | 7.33 | 1.38 | 0.87 | 2.19 | 1.15 | 0.72 | 1.85 | 16 | 5.86 | 1.45 | 0.86 | 2.42 | 1.26 | 0.74 | 2.13 |
| ART | 487 | 49 | 10.06 | 1.95 | 1.43 | 2.65 | 1.50 | 1.08 | 2.09 | 25 | 5.13 | 1.26 | 0.83 | 1.91 | 1.03 | 0.67 | 1.60 |
| Fine motor | |||||||||||||||||
| Natural conception | 8895 | 389 | 4.37 | ref | ref | 513 | 5.77 | ref | ref | ||||||||
| OI/AIH | 273 | 17 | 6.23 | 1.45 | 0.88 | 2.40 | 1.28 | 0.76 | 2.13 | 19 | 6.96 | 1.22 | 0.76 | 1.97 | 1.20 | 0.74 | 1.96 |
| ART | 487 | 34 | 6.98 | 1.64 | 1.14 | 2.36 | 1.27 | 0.86 | 1.86 | 31 | 6.37 | 1.11 | 0.76 | 1.62 | 1.05 | 0.71 | 1.56 |
| Problem solving | |||||||||||||||||
| Natural conception | 8895 | 354 | 3.98 | ref | ref | 505 | 5.68 | ref | ref | ||||||||
| OI/AIH | 273 | 13 | 4.76 | 1.21 | 0.68 | 2.13 | 0.90 | 0.50 | 1.60 | 18 | 6.59 | 1.17 | 0.72 | 1.91 | 1.20 | 0.73 | 1.99 |
| ART | 487 | 32 | 6.57 | 1.70 | 1.17 | 2.47 | 1.18 | 0.79 | 1.75 | 27 | 5.54 | 0.98 | 0.66 | 1.45 | 0.91 | 0.60 | 1.38 |
| Personal-social | |||||||||||||||||
| Natural conception | 8895 | 449 | 5.05 | ref | ref | 400 | 4.5 | ref | ref | ||||||||
| OI/AIH | 273 | 24 | 8.79 | 1.81 | 1.18 | 2.79 | 1.46 | 0.93 | 2.28 | 16 | 5.86 | 1.32 | 0.79 | 2.21 | 1.20 | 0.70 | 2.04 |
| ART | 487 | 42 | 8.62 | 1.78 | 1.28 | 2.47 | 1.25 | 0.88 | 1.77 | 28 | 5.75 | 1.30 | 0.87 | 1.92 | 1.05 | 0.69 | 1.60 |
Multivariable logistic models were adjusted for maternal age, parity, gestational week (<37 weeks), child sex, birth defect, multiple birth, maternal education level and household income.
AIH, artificial insemination with husband’s semen; ART, assisted reproductive technology; OI, ovulation induction.