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. 2022 May 23;10(5):e004644. doi: 10.1136/jitc-2022-004644

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Enhanced survival outcomes, resulting from IDH1^R132H inhibition, depend on activity of both CD4⁺ and CD8⁺ T-cells. (A) Schematic description of the T-cell depletion treatment regimen. (B) Kaplan-Meier survival curve. *P<0.05, **p<0.002; log-rank test.