Table 3.

Univariate and multivariate survival analysis for Overall Survival (OS)

	Univariate Cox regression			~OS	Multivariate Cox Regression			~OS
Parameter	HR	95% CI		P	HR	95% CI		P
Age at Resection	1.01	0.99 to 1.04		0.34	n.i.
<70	0.99	0.55 to 1.79		0.98
≥70
Sex	1.13	0.63 to 2.04		0.69	n.i.
Female
Male
Ethnicity					n.i.
Caucasian	0.91	0.36 to 2.33	0.85
Black	1	0 to 6.51	0.79
Asian
Hispanic	0.00	0.00	NA	1.00
Not Reported	0.00	0.00	NA	1.00
chronic Hepatis B/C-virus infection					n.i.
Yes	0.33	2.70 to 0.92		0.94
No
Not Reported	0.55	2.13 to 0.81
Clinical PSC	0.58	6.25 to 0.28		0.28	n.i.
Tumorsize	0.63	0.35 to 1.15		0.13	n.i.
<5.89 cm
≥ 5.89 cm
T-Classification	1.59	1.14 to 2.23		0.01*	0.48	0.22 to 1.04		0.06
N-Classification	1.00	0.99 to 1.00		0.75	1.00	0.99 to 1.00		0.26
AJCC 8th edition stage	2.64	1.75 to 3.99		<0.001*	2.70	1.39 to 5.25		<0.01*
Lymphangioinvasion	2.97	1.55 to 5.68		0.001*	2.61	1.12 to6.05		0.03*
Satellite Nodule Mass	1.79	0.79 to 4.04		0.16	n.i.
Capsule Involvement	2.86	1.10 to 7.44		0.03*	2.64	0.70 to 9.99		0.15
Periductal infiltrating type	1.00	0.99 to 1.00		0.18	1.00	0.99 to 1.00		0.17
adjuvant Radiotherapy	1.99	1.09 to 3.63		0.02*	2.21	1.02 to 4.80		0.04*
Tumor budding peritumoral	3.65	2.18 to 6.13		<0.001*	3.30	1.82 to 6.02		<0.001*
Tumor budding intratumoral	3.49	2.19 to 5.54		<0.001*	3.54	2.15 to 5.83		<0.001*
Tumor budding compiled	3.60	2.21 to 5.89		<0.001*	3.28	1.94 to 5.52		<0.001*
n.i. = not included *P<0.05