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. 2022 May 13;13(8):2559–2569. doi: 10.7150/jca.71894

Figure 5.

Figure 5

Blockage of the β-catenin expression in the HK2 over-expressed cells by using XAV939. The western blotting was used to detected the expression of β-catenin, c-myc and CyclinD1 in XAV939 treated OVCA433-HK2 (A) SKOV3-HK2 (D)cells, and the quantitative analysis is shown. The growth curves (B) and MTT assay (C) was used to detected the proliferation and viability of XAV939 treated OVCA433-HK2 cells. The growth curves (E) and MTT assay (F) was used to detected the proliferation and viability of XAV939 treated SKOV3-HK2. (G) The soft agar assay for colony formation were used to detected the cell proliferation in XAV939 treated OVCA433-HK2 and SKOV3-HK2 cells. (H) The positive correlation between HK2 and β-catenin, c-myc, CyclinD1 expression in ovarian serous cystadenocarcinoma were confirmed from the GEPIA online database. (I) Proposed model of the HK2 promoted cell proliferation and tumor growth in human ovarian cancer. The data were shown as the mean±SD of three independent experiments. * p<0.05, ** p<0.01 vs. control using One-Way ANOVA.