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. 2022 May 25;10:851042. doi: 10.3389/fped.2022.851042

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Copyright © 2022 Mikolajcikova, Lasabova, Holubekova, Skerenova, Zibolenova, Matasova, Zibolen and Calkovska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The reference transcript for the SFTPB gene (green section) and the SP-B preprotein (red section). The SFTPB gene reference transcript ENSG00000168878 is composed of 11 exons, with dark green rectangles aligning the exons that encode the SP-B preprotein, which is composed of 381 amino acid residues (CCDS1983.2, red section below transcript). The mature SP-B protein contains amino acid residues at codons 201 to 279 (28, 29), and protein-encoding exons 6 and 7 are indicated by a large red rectangle. Three of the tagged SNPs (rs893159, rs2304566, and rs762548) are in the second exon encoding mature SP-B, and SNP rs9752 is at 3′UTR in the flanking arm of the preprotein (light green transcript rectangle). https://www.ncbi.nlm.nih.gov/gene/6439 (modified).