Table 3.

Role of Trichoderma spp. genes involved in the antagonism and synthesis of secondary metabolites deleterious to R. solani.

Pathways	Protein/molecule	Gene	Trichoderma spp.	References
Pyrone biosynthesis pathway	Lipoxygenase	lox1	T. atroviride	Kubicek et al., 2011; Speckbacher et al., 2020
	6-Pentyl-α-pyrone (6-PP)	N.A.	Trichoderma spp.	Kotasthane et al., 2015
Polyketide biosynthesis pathway	Polyketide synthases (PKS)	pks4	T. reesei	Atanasova et al., 2013b
		pks4	T. virens	Atanasova et al., 2013b
		pks4	T. atroviride	Atanasova et al., 2013b
Peptaibol biosynthesis pathway	Non-ribosomal peptide synthetases (NRPS)	tex1	T. asperellum	Rahimi Tamandegani et al., 2020
Gliotoxin and gliovirin biosynthesis pathway	Aminotransferase	gliI	T. virens	Atanasova et al., 2013a
	GliC Cytochrome P450	gliC	T. virens	Atanasova et al., 2013a
	GliC Cytochrome P450	gliF	T. virens	Atanasova et al., 2013a
	ɣ-Glutamyl cyclotransferase-like protein	gliK	T. virens	Atanasova et al., 2013a
	Glutathione S-transferase	gliG	T. virens	Atanasova et al., 2013a
	Methyltransferase	gliN	T. virens	Atanasova et al., 2013a
	NRPS modules	gliP	T. virens	Atanasova et al., 2013a
	O-Methyltransferase	gliM	T. virens	Atanasova et al., 2013a
Terpenoid/steroid synthesis pathway	Cytochrome P450 monooxygenases	tri4	T. arundinaceum	Malmierca et al., 2012
	Hydroxy-methylglutaryl-CoA reductase	hmgR	T. harzianum	Cardoza et al., 2007
	Major facilitator superfamily transporter	Thmfs1	T. harzianum	Liu et al., 2012
	Trichodiene synthase	tri5	T. arundinaceum	Malmierca et al., 2013
Oxidases	L-Amino acid oxidase	Th-LAAO	T. harzianum	Yang et al., 2011
Other’s proteins	4-Phosphopantetheinyl transferase	ppt1	T. virens	Cheng et al., 2011
Transporters	ABC transporters	Taabc2	T. atroviride	Ruocco et al., 2009
Miscellaneous	CoA reductase	hmgR	T. koningii	Gajera et al., 2016
	Mitogen-activated protein kinase	task1	T. asperellum	Yang, 2017
	Harzianic acid (HA)		T. harzianum	Manganiello et al., 2018
	Helicase-related proteins	ipa-1	Trichoderma virens	Estrada-Rivera et al., 2020
	p450 Monooxygenases	TvCyt2	Trichoderma virens	Ramírez-Valdespino et al., 2018