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. 2022 May 25;16:834780. doi: 10.3389/fnins.2022.834780

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Copyright © 2022 Rechtzigel, Meyerink, Leppert, Johnson, Cain, Ferrandino, May, Roux, Brudvig and Weimer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CLN3, CLN6, and CLN8-BioID share a core set of protein interactors with roles in vesicular sorting and presynaptic function. (A) RNAscope transcript localization indicates cellular co-occurrence of CLN3, CLN6, and CLN8 in the P21 mouse cortex. (B) Venn diagram depicting the number of significantly enriched proteins for each bait protein. (C) ClueGO network of significantly enriched Gene Ontology Consortium (GO) cellular compartment terms of common BioID interactors, with a box indicating categories involved in vesicle trafficking and sorting. (D) Shared protein interactors are associated with key cellular compartment terms. (E) KEGG Functional terms with corresponding proteins from common BioID interactors.