TABLE 1.
Demographic and clinical characteristics of subjects included in the study.
| Characteristics | AD (n = 246) | CN (n = 244) | P-value |
| Age, years | 71.26 ± 8.46 | 71.10 ± 8.31 | 0.835 |
| Education, years | 8.82 ± 4.53 | 10.90 ± 3.84 | <0.001 |
| MMSE | 15.72 ± 6.28 | 28.81 ± 1.26 | <0.001 |
| Female, n (%) | 137 (55.69) | 137 (56.15) | 0.919 |
| APOE genotype, n (%) | |||
| ε2/ε2 | 2 (0.81) | 2 (0.82) | |
| ε2/ε3 | 20 (8.13) | 28 (11.48) | |
| ε2/ε4 | 4 (1.63) | 5 (2.05) | |
| ε3/ε3 | 98 (39.84) | 160 (65.57) | |
| ε3/ε4 | 90 (36.59) | 49 (20.08) | |
| ε4/ε4 | 32 (13.01) | 0 (0) | |
| APOE ε4 carriers, n (%) | 126 (51.22) | 54 (22.13) | <0.001 |
AD, Alzheimer’s Disease; APOE, Apolipoprotein E; MMSE, Mini Mental Status Evaluation. Demographic data were measured using non-parametric Mann-Whitney U-test for skewed distribution variable. For gender, genotype distribution and allele frequencies, values were expressed as number (%) using chi-square test. Bold values denote significant difference.