Table 1.

List of genetic instruments for obesity and log odds ratios of hypertension disorders in pregnancy risk by each instrumental SNP (GWAS significance with P < 5× 10⁻⁸ and linkage disequilibrium threshold with R² < 0.001).

No	SNP	Gene	Chr	EA	OA	EAF.obesity	EAF.HDP	Obesity β(SE)	HDP β(SE)
1	rs987237	TFAP2B	6	A	G	0.10	0.79	0.13	−0.06
2	rs13393304	_	2	G	A	0.89	0.84	0.18	0.06
3	rs13130484	_	4	C	T	0.42	0.52	0.11	−0.03
4	rs7138803	_	12	A	G	0.44	0.38	0.08	0.04
5	rs527248	_	1	A	G	0.26	0.82	0.11	−0.06
6	rs887912	_	2	T	C	0.62	0.25	−0.08	−0.01
7	rs10182181	_	2	A	G	0.50	0.58	0.07	0.03
8	rs9816226	_	3	T	A	0.85	0.85	0.11	0.06
9	rs2307111	POC5	5	T	C	0.43	0.58	−0.07	−0.02
10	rs4929923	TRIM66	11	T	C	0.73	0.34	0.08	−0.04
11	rs8028313	MAP2K5	15	G	C	0.78	0.22	−0.10	−0.06
12	rs11075989	FTO	16	C	T	0.44	0.41	0.21	−0.09
13	rs523288	_	18	T	A	0.62	0.29	0.13	0.03
14	rs29939	_	19	A	G	0.22	0.67	0.07	0.01

Chr. indicates chromosome; EA, effect allele; OA, other allele; EAF, effect allele frequency. A total of 14 genetic instruments were included in the present MR analysis, located in four genes (POC5, TRIM66, MAP2K5, and FTO) and 12 chromosomes (1, 2, 3, 4, 5, 6, 11, 12, 15, 16, 18, and 19) with an effect allele frequency (EAF) of 0.1–0.9 in SNPs of obesity and 0.2–0.9 in SNPs of hypertension disorders in pregnancy.