TABLE 1.

The pharmacokinetic parameters from non-compartment analysis.

Determination of	Parameters	10 mg/kg		20 mg/kg
		Mean	CV (%)	Mean	CV (%)
I.V. administration of Rh2
Rh2	Vss (L/kg)	17.1	86.9	20.2	77.1
	AUC0-t (h∙nmol/L)	1457	42.2	3,850	77.5
	t1/2 (h)	2.23	10.6	2.36	29.0
PPD	Cmax (nmol/L)	94.9	22.9	174	31.7
	Tmax (h)	6.83	85.4	6.75	88.5
	AUC0-t (h∙nmol/L)	1039	37.7	2,827	40.5
P.O. administration of Rh2
PPD	Cmax (nmol/L)	255	17.1	442	49.5
	Tmax (h)	8.00	0.00	10.7	21.7
	AUC0-t (h∙nmol/L)	2,377	15.3	4,611	44.8