TABLE 2.
Summary of estimated pharmacokinetic parameters.
| Parameters | Definition | Estimate | CV% | 95% CI | |
|---|---|---|---|---|---|
| Lower | Upper | ||||
| Rh2 independent parameters after I.V. administration of Rh2 | |||||
| VRh2, plasma (L/kg) | Volume of central compartment distribution of Rh2 | 2.39 | 16.4 | 1.54 | 3.23 |
| Ke (1/h) | Elimination rate constant of Rh2 in central compartment | 4.67 | 3.90 | 4.28 | 5.07 |
| K47 (1/h) | Transfer rate constant of Rh2 from central compartment to peripheral compartment | 2.08 | 14.8 | 1.42 | 2.75 |
| K74 (1/h) | Transfer rate constant of Rh2 from peripheral compartment to central compartment | 0.48 | 15.0 | 0.32 | 0.63 |
| PPD independent parameters after I.V. administration of PPD | |||||
| VPPD, plasma (L/kg) | Volume of central compartment distribution of PPD | 0.29 | 27.0 | 0.13 | 0.44 |
| K50 (1/h) | Elimination rate constant of PPD in central compartment | 4.88 | 29.3 | 1.99 | 7.77 |
| K58 (1/h) | Transfer rate constant of PPD from central compartment to peripheral compartment | 27.3 | 19.5 | 16.5 | 38.0 |
| K85 (1/h) | Transfer rate constant of PPD from peripheral compartment to central compartment | 3.38 | 9.68 | 2.72 | 4.04 |
| PPD parameters after I.V. administration of Rh2 | |||||
| K45 (1/h) | Transformation rate constant from Rh2 to PPD in systemic circulation | 0.09 | 12.9 | 0.07 | 0.12 |
| K43 (1/h) | Excretion rate constant of Rh2 in bile | 1.29 | NA | NA | NA |
| K40 (1/h) | Elimination rate constant of Rh2 by other routes in systemic circulation | 3.29 | NA | NA | NA |
| K60 (1/h) | Elimination rate constant of PPD in colon | 1.38 | 16.1 | 0.90 | 1.85 |
| Kt (1/h) | Transit rate constant of Rh2 in intestines | 0.63 | 7.53 | 0.53 | 0.73 |
| PPD parameters after P.O. administration of Rh2 | |||||
| K13 (1/h) | Transit rate constant of Rh2 from stomach to duodenum | 0.22 | 9.66 | 0.17 | 0.26 |
| K12 (1/h) | Transformation rate constant from Rh2 to PPD in stomach | 0.14 | 14.5 | 0.10 | 0.18 |
| K20 (1/h) | Elimination rate constant of PPD in stomach | 22.2 | 20.6 | 12.6 | 31.8 |
NA, not available. The estimates of k43 and k40 have been frozen. CI, confidence interval.