Table 1.

The types of EVs.

Classification	Subtypes	Diameter	Source	Marker	Ref
Physical characteristics/Size	sEV	< 200nm	Originates from the inward outgrowth of multivesicular bodies (MVB), endosomal system	Transmembrane proteins CD9, CD63 and CD81; ALIX; TSG101	(5, 22, 29)
			Derived from hepatocytes, macrophages, NK cells, T cells, B cells
	m/lEV	> 200nm	Plasma membrane outward budding production	Integrin; Selectin; CD40; Most membrane-associated proteins in source cells	(30, 31)
			Derived from almost all healthy living cells.
Descriptions of conditions/Cell of origin	Apoptotic body	1-5μm	generated from cell fragments undergoing apoptosis	Phosphatidylserine; Genomic DNA; It is similar to the surface markers of its derived cells and rich in caspases-3 and caspases-7	(30, 32)
	Large oncosome	1-10μm	originates from the shedding of the membrane bubbles	CK18	(33–36)
			released by Invasive prostate cancer cells, urinary bladder, and glioblastoma
	Hypoxic EV	–	Hypoxic cell	include mRNA and proteins (MMPs, IL-8, PDGFs, caveolin 1, and lysyl oxidase, etc)	(37, 38)
	Podocyte EV	–	from the tip of the microvilli of the podocytes	—	(39)