Table 3.
Changes in parameters of plasma samples between TDF, TAF and ABC after 12 weeks of treatment. Data are presented as median and quartiles (percentiles of 25% and 75%) and were compared using the Wilcoxon rank test. Statistical significance was considered for p <0.05. p: 12 weeks vs baseline; p1: TDF vs TAF (12 weeks vs baseline); p2: TDF vs ABC (12 weeks vs baseline); p3: TAF vs ABC (12 weeks vs baseline).
| Parameters Increments Baseline: 12 Weeks After Initiating Treatment | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | TDF | TAF | ABC | - | |||||
| Median (Q1, Q3) | p | Median (Q1, Q3) | p | Median (Q1, Q3) | p | p1 | p2 | p3 | |
| Ca | 0.53 (-0.53, 5.53) | 0.286 | 2.06 (-2.59, 5.53) | 0.374 | 0.00 (-3.06, 5.29) | 0.858 | 0.745 | 0.643 | 0.802 |
| P | -2.86 (-21.8, 18.4) | 0.629 | 3.70 (-2.63, 18.4) | 0.182 | 2.94 (-4.18, 25.3) | 0.166 | 0.256 | 0.165 | 0.962 |
| 25 OH Vit. D | -10.8 (-25.9, 156) | 0.980 | 47.8 (1.88, 156) | 0.003 | 2.73 (-28.6, 21.3) | 0.336 | 0.044 | 0.403 | 0.031 |
| CD4 | 26.5 (-4.91, 46.9) | 0.016 | 29.2 (2.00, 46.9) | 0.001 | 43.9 (22.6, 41.0) | <0.001 | 0.961 | 0.521 | 0.518 |
| CD8 | -11.6 (-22.8, 28.6) | 0.744 | 5.24 (-29.1, 28.6) | 0.798 | -3.47 (-21.2, 3.53) | 0.779 | 0.683 | 0.521 | 0.825 |
| CD4/CD8 ratio | 49.3 (15.9, 87.7) | 0.001 | 30.4 (7.58, 87.7) | 0.001 | 43.6 (10.8, 35.3) | <0.001 | 0.635 | 0.476 | 0.975 |
| Cholesterol | -1.90 (-12.0, 39.3) | 1.000 | 27.3 (10.2, 39.3) | <0.001 | 13.5 (1.76, 19.0) | 0.002 | 0.001 | 0.021 | 0.046 |
| Triglycerides | -0.96 (-6.50, 57.7) | 0.404 | 34.9 (10.6, 57.7) | 0.003 | -0.08 (-25.9, 41.2) | 0.224 | 0.124 | 0.823 | 0.138 |
| CTX | 62.1 (-6.56, 73.7) | 0.064 | 42.6 (-0.36, 73.7) | 0.011 | 54.2 (-3.13, 53.0) | 0.002 | 0.635 | 0.723 | 0.523 |
| P1NP | 31.7 (25.7, 38.0) | 0.004 | 3.79 (-15.9, 38.0) | 0.243 | 17.2 (4.16, 35.0) | 0.001 | 0.075 | 0.128 | 0.255 |
| OC | 38.6 (22.2, 62.7) | 0.001 | 27.3 (10.8, 62.7) | 0.001 | 13.9 (0.97, 67.6) | 0.001 | 0.433 | 0.096 | 0.435 |
| TRAP | 11.1 (7.69, 45.5) | 0.003 | 21.0 (-3.45, 45.5) | 0.008 | 20.0 (2.08, 15.5) | 0.002 | 0.564 | 0.939 | 0.824 |
| PTH | -1.88 (-37.4, 27.4) | 1.000 | -5.76 (-18.0, 27.4) | 0.934 | 11.5 (-25.3, 114) | 0.674 | 0.800 | 0.627 | 0.581 |
| DKK1 | -21.0 (-58.0, 25.3) | 0.098 | -15.7 (-60.1, 25.3) | 0.515 | -16.8 (-47.7, 37.6) | 0.007 | 0.707 | 0.736 | 0.766 |
| OPG | -23.4 (-41.5, 2.54) | 0.003 | -28.8 (-40.4, 2.54) | 0.049 | -11.9 (-37.6, 60.7) | 0.294 | 0.683 | 0.114 | 0.292 |
| OPN | 19.3 (-3.53, 45.1) | 0.045 | 13.6 (-6.93, 45.1) | 0.104 | 0.75 (-14.3, 30.5) | 0.670 | 0.552 | 0.107 | 0.269 |
| SOST | -9.8 (-26.3, 15.1) | 0.074 | -30.5 (-47.8, 15.1) | 0.216 | -8.77 (-24.7, 52.5) | 0.646 | 0.880 | 0.268 | 0.227 |
| RANKL | 17.7 (-29.5, 23.2) | 0.610 | 0.00 (-0.19, 23.2) | 0.675 | 0.00 (-12.4, 16.8) | 0.162 | 0.859 | 0.853 | 0.534 |
| OPG/RANKL | -23.08 (-62.23, 23.67) | 0.413 | -33.67 (-79.32, 71.60) | 0.922 | -23.24 (-90.89, 29.21) | 0.165 | 0.875 | 0.625 | 0.437 |