Table 4.
Changes in parameters of plasma samples between TDF, TAF and ABC after 48 weeks of treatment. Data are presented as median and quartiles (percentiles of 25% and 75%) and were compared using the Wilcoxon rank test. Statistical significance was considered for p <0.05. p: 48 weeks vs baseline; p1: TDF vs TAF (48 weeks vs baseline); p2: TDF vs ABC (48 weeks vs baseline); p3: TAF vs ABC (48 weeks vs baseline).
| Parameters Increment Baseline: 48 Weeks After Initiating Treatment | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | TDF | TAF | ABC | - | |||||
| Median (Q1, Q3) | p | Median (Q1, Q3) | p | Median (Q1, Q3) | P | p1 | p2 | p3 | |
| Ca | 2.17 (1.06, 4.48) | 0.005 | 2.11 (-1.59, 4.48) | 0.095 | 1.52 (-2.28, 1.05) | 0.182 | 0.367 | 0.030 | 0.278 |
| P | -5.30 (-20.2, 18.2) | 0.404 | -3.03 (-7.69, 18.2) | 0.660 | 0.00 (-6.27, 25.0) | 0.465 | 0.345 | 0.153 | 0.655 |
| 25 OH Vit. D | 29.4 (-9.24, 44.9) | 0.083 | 15.1 (-11.7, 44.9) | 0.041 | 26.8 (-14.8, 42.6) | 0.021 | 0.823 | 0.914 | 0.607 |
| CD4 | 24.4 (-10.1, 98.1) | 0.074 | 29.4 (8.92, 98.1) | 0.001 | 45.6 (26.4, 162) | <0.001 | 0.523 | 0.120 | 0.349 |
| CD8 | -28.8 (-41.3, 20.6) | 0.051 | -0.27 (-44.6, 20.6) | 0.922 | -12.2 (-38.5, 16.0) | 0.516 | 0.367 | 0.117 | 0.987 |
| CD4/CD8 ratio | 102 (26.7, 130) | <0.001 | 75.0 (35.1, 130) | <0.001 | 65.3 (33.4, 170) | <0.001 | 0.756 | 0.732 | 0.912 |
| Cholesterol | 10.7 (0.53, 31.6) | 0.025 | 19.4 (11.1, 31.6) | 0.001 | 19.2 (-0.40, 31.5) | 0.001 | 0.333 | 0.604 | 0.592 |
| Triglycerides | -1.19 (-24.2, 49.3) | 0.860 | 34.8 (-17.7, 49.3) | 0.029 | 6.38 (-19.2, 142) | 0.198 | 0.088 | 0.134 | 0.975 |
| CTX | 92.3 (17.9, 81.8) | <0.001 | 31.6 (10.3, 81.8) | 0.027 | 45.0 (12.8, 122) | <0.001 | 0.139 | 0.615 | 0.166 |
| P1NP | 81.4 (47.5, 53.4) | <0.001 | 17.8 (6.68, 53.4) | 0.017 | 21.4 (2.84, 70.7) | 0.001 | 0.038 | 0.015 | 0.878 |
| OC | 49.6 (42.7, 50.7) | <0.001 | 1.65 (-10.0, 50.7) | 0.024 | 20.1 (-9.34, 126) | 0.011 | 0.033 | 0.083 | 0.275 |
| TRAP | 51.1 (23.1, 244) | 0.002 | 120 (31.5, 244) | <0.001 | 68.1 (23.3, 56.5) | <0.001 | 0.091 | 0.797 | 0.052 |
| PTH | 35.8 (12.3, 54.7) | 0.078 | 47.6 (-7.11, 54.7) | 0.027 | 22.2 (-8.25, 82.8) | 0.055 | 0.817 | 0.469 | 0.468 |
| DKK1 | 67.4 (-18.2, 17.8) | 0.049 | -12.3 (-50.5, 17.8) | 0.241 | -8.08 (-37.8, -17.7) | 0.582 | 0.046 | 0.096 | 0.647 |
| OPG | 20.1 (-12.2, 54.1) | 0.244 | 0.67 (-38.5, 54.1) | 0.623 | -11.8 (-32.5, 67.8) | 0.218 | 0.472 | 0.330 | 0.904 |
| OPN | 63.5 (16.5, 39.5) | 0.013 | 23.4 (-19.0, 39.5) | 0.123 | -1.59 (-27.1, 5.47) | 0.645 | 0.132 | 0.015 | 0.222 |
| SOST | 20.2 (-30.0, 95.5) | 0.497 | 16.9 (-37.3, 95.5) | 0.296 | -12.3 (-20.8, 78.6) | 0.275 | 0.943 | 0.814 | 0.890 |
| RANKL | 980 (588, 1425) | 0.004 | 302 (-72.2, 1425) | 0.164 | 1067 (325, 1619) | 0.001 | 0.278 | 0.769 | 0.258 |
| OPG/RANKL | -84.91 (-91.90, -59.94) | 0.105 | -62.41 (-85.96, 597.6) | 0.750 | -85.42 (-95.92, 31.37) | 0.275 | 0.500 | 0.500 | 0.500 |