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Metabolism of enflicoxib in intestinal microsomes from rats and dogs.
| Metabolite | Parameter | Species | Ratio Dog/Rat | |
|---|---|---|---|---|
| Wistar Rat | Beagle Dog | |||
| Enflicoxib | Relative % | 99.86 | 98.27 | - |
| Rate | nd | nd | nd | |
| M8 | Relative % | 0.03 | 1.38 | - |
| Rate | 0.06 | 2.08 | 37.0 | |
| E-6132 | Relative % | 0.11 | 0.33 | - |
| Rate | 0.19 | 0.50 | 2.6 | |
nd not determined
Rate calculated for the time range 0-120 min (pmol min-1 mg-1)
Relative % (120 min): molar amount expressed as percentage of parent enflicoxib after 120 mi. incubation
