Table 4.

Secondary metabolism of M8 and E-6132 metabolites in liver microsomes from rats and dogs.

Metabolite	Time (min)	LC-MS Peak Area
		Substrate: M8		Substrate: E-6132
		Wistar Rat	Beagle Dog	Wistar Rat	Beagle Dog
Unchanged enflicoxib	0	0	0	0	0
	60	0	0	0	0
	120	0	0	0	0
M7	0	0	0	0	0
	120	3.04	1.31	0	0
	180	2.93	1.68	0	0
M8	0	81.35	87.95	0	0
	120	81.51	90.49	0	0
	180	89.97	97.61	0	0
E-6132	0	0	0	148.23	122.31
	120	0	0	128.54	128.65
	180	0	0	152.20	149.00