Fig. (4).

Logical representation of the effects of treating cells with PMPMEase irreversible inhibitor, L-28 and PCAIs, and the possible interactions resulting in such effects. Some of the protein-protein interactions of the polyisoprenylated proteins are dependent on the polyisoprenyl moiety (P) [16]. The PCAIs possibly interfere with those interactions between the G-proteins and their effector (E) dependent on the polyisoprenyl cysteine, thereby disrupting the functional interactions and the subsequent events [46, 47, 50, 51]. (A higher resolution / colour version of this figure is available in the electronic copy of the article).