Fig (5).

Possible interactions of PCAIs with polyisoprenylated protein chaperones. PCAIs may competitively disrupt the well-defined polyisoprenylation-dependent interactions of polyisoprenylated proteins (P protein) with chaperone proteins [16], resulting in their dislodgement such that their localizations, functions, biotransformation and breakdown patterns become altered. This is exemplified by the phosphorylation of the hypervariable region of K-Ras4B that is inhibited by its binding to CaM, thereby controlling its polyisoprenylation-dependent interactions [87] and depletion of K-Ras [50], RhoA, Rac1 and Cdc42 [48]. (A higher resolution / colour version of this figure is available in the electronic copy of the article).