Table 1.
Representative bacterial Zn2+ specific substrate-binding proteins of cluster A-I. A three-dimensional structure of the protein in the zinc bound form is available for the underlined species. Hypothetical zinc coordination mode for SBP lacking a 3D structure is written in italics.
| Protein | Coordination Mode | SBP Classification | Species | Refs. | |
|---|---|---|---|---|---|
| AdcAII | 3His, 1Glu | Ia | lipid-anchored | S. pneumoniae(G+), | [41] |
| 3His, 1Glu or H2O | S. agalactiae (G+) | ||||
| Lbp (or Lsp) |
3His, 1Glu | Ia | Lipid-anchored | S. pyogenes (G+) | [51] |
| Lmb | 3His, 1Glu | Ia | Lipid-anchored | S. agalactiae (G+) | [52] |
| AdcA |
3His, 1Glu or H2O (N-terminal domain); 3His (C-terminal domain) |
Ib | Lipid-anchored | S. pneumoniae (G+), S. agalactiae (G+), S. pyogenes (G+) | [53] |
| ZnuA | 3His, 1Glu | II | Soluble | E. coli (G-), S. enterica (G-) | [46, 54, 55] |
| 3His, 1H2O |
P. aeruginosa (G-), T. pallidum (G-), H. ducreyi (G-), H. influenzae (G-), Y. pestis (G-) |
||||
| TroA | 3His, 1Asp | III | Lipid-anchored | T. pallidum (G-), S. suis (G+) | [56, 57] |