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. 2022 Jun 8;10(11):e15342. doi: 10.14814/phy2.15342

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© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hypoxic conditioned media from hPMVEC activated EGFR in hPASMC. hPASMC were serum‐starved overnight and then treated with NCM or HCM for 5 minutes. Cells were then harvested for western blots. (a) Representative western blots for phosphorylated EGFR (pEGFR), total EGFR, and β‐actin. (b) Densitometry for pEGFR normalized to total EGFR. HCM treated hPASMC had significantly greater levels of pEGFR than did NCM treated hPASMC. *HCM different from NCM, p < 0.05. n = 5 in each group. (c) Densitometry for pEGFR normalized to β‐actin. HCM treatment of hPASMC resulted in significantly greater levels of pEGFR than in NCM treated hPASMC. *HCM different from NCM, p < 0.01. n = 5 for each group.