. Author manuscript; available in PMC: 2022 Jun 8.

Published in final edited form as: ACS Biomater Sci Eng. 2022 Mar 31;8(4):1686–1695. doi: 10.1021/acsbiomaterials.2c00043

Table 2.

Fitting parameters for the one-compartment pharmacokinetic model. C₀ represents the first MVD value detected in blood at 1 min after injection and k_e the clearance rate constant. Data represents the mean ± standard deviation for three different experiments.


	C₀ (μL/kg)			k_e (min⁻¹)

MVD (μL/kg)	2 μm	3 μm	5 μm	2 μm	3 μm	5 μm
5	3.1 ± 0.9	4.0 ± 0.5	4.6 ± 0.4	0.74 ± 0.12	0.50 ± 0.11	0.44 ± 0.05
10	9.6 ±0.7	9.8 ±0.5	10.7 ± 1.5	0.38 ±0.06	0.35 ± 0.02	0.34 ±0.06
20	16.3 ±2.0	18.2 ± 1.1	-	0,50 ±0.06	0.53 ±0.10	-