Table 1.
Baseline and 2‐year change characteristics of cohort stratified by median value of baseline hs‐CRP
| Variable | Entire cohort (n = 142) | Low hs‐CRP (n = 76) | High hs‐CRP (n = 66) | p |
|---|---|---|---|---|
| Demographic and clinical characteristics | ||||
| Age (years) | 65 ± 6.3* | 64.7 ± 6.0 | 65.3 ± 6.8 | .57 |
| Males | 92 (64) | 53 (70) | 39 (59) | .19 |
| Hypertension | 70 (49) | 31 (41) | 39 (59) | .03 |
| Diabetes mellitus | 10 (7) | 4 (5) | 6 (9) | .37 |
| Body mass index | 27 (25–29) | 27 (24–28) | 29 (27–31) | <.001 |
| Current smoker | 7 (5) | 3 (4) | 4 (6) | .59 |
| Framingham Risk Score | 7.3 (3.1–12.7) | 7.1 (2.9–11.8) | 8.2 (3.2–14.3) | .19 |
| Clinical and lab values | ||||
| Total cholesterol, mg/dl | 177 (154–199) | 171 (148–188) | 181 (159–202) | .06 |
| Delta (2‐year) | −14 (−40 to 4) | −12 (−29 to 6) | −21 (−53 to 1) | .05 |
| HDL cholesterol, mg/dla | 57 (46–70) | 58 (48–75) | 57 (45–69) | .26 |
| Delta (2‐year) | 2 (−5 to 7) | 3 (−4 to 10) | 1 (−5 to 5) | .16 |
| LDL cholesterol, mg/dla | 90 (76–105) | 87 (75–97) | 97 (77–113) | .01 |
| Delta (2‐year) | −15 (−29 to −1) | −13 (−25 to −2) | −18 (−35 to −1) | .10 |
| Triglycerides, mg/dl | 107 (72–138) | 96 (67–121) | 118 (78–149) | .03 |
| Delta (2‐Year) | −9 (−32 to 13) | −10 (−32 to 10) | −8 (−27 to 14) | .79 |
| CAC score | 65 (1–380) | 54 (1–320) | 67 (0–467) | .98 |
| Delta (2‐year) | 13 (0–80) | 12 (1–78) | 14 (0–90) | .82 |
| hs‐CRP, mg/La | 1.0 (0.5–2.1) | 0.5 (0.3–0.8) | 2.2 (1.6–4.2) | .00 |
| Delta (2‐year) | 0.05 (−0.4 to 0.51) | 0.16 (−0.05 to 0.4) | −0.43 (−2.31 to 0.64) | .001 |
| log (hs‐CRP) | −0.01 (−0.76 to 0.76) | −0.65 (−1.2 to −0.29) | 0.77 (0.44–1.44) | <.001 |
| Delta (2‐year) | 0.10 (−0.41 to 0.63) | 0.36 (−0.11 to 0.75) | −0.30 (−0.84 to 0.33) | <.001 |
| * Coronary artery characterization | ||||
| Noncalcified coronary burden, (mm2×100) | 3.5 (0.2–14.1) | 3.3 (0.4–14.0) | 3.6 (0.1–15.4) | .99 |
| Delta (2‐year), (mm2×100) | 0.17 (−0.41to 2.27) | 0.24 (−0.44 to 2.28) | 0.06 (−0.07 to 2.27) | .87 |
| Dense‐calcified coronary burden, (mm2×100) | 6.5 (0.22–37.2) | 6.5 (0.5–37) | 6.1 (0–37.2) | .84 |
| Delta (2‐Year), (mm2×100) | 0.90 (−0.33 to 5.26) | 0.32 (−0.08 to 2.50) | 1.27 (0–9.80) | .02 |
| Carotid artery characterization | ||||
| Carotid artery thickness (mm3) | 127 (109–148) | 128 (110–146) | 126 (102–153) | .65 |
| Delta (2‐year) | −4.96 (−17.9 to 7.88) | −2.38 (−19.3 to 7.88) | −6.13 (−14.9 to 11.0) | .94 |
*
Values are mean ± SD or median (IQR) for continuous data and N (%) for categorical data. Bolded p values are significant.
a
HDL cholesterol: high‐density lipoprotein cholesterol; LDL cholesterol: low‐density lipoprotein cholesterol; hs‐CRP: high sensitivity C‐reactive protein.