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. 2022 Jun 8;12(6):220019. doi: 10.1098/rsob.220019

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — Correlations of binding affinities (pK_i values) of ligands to M₄ receptor, measured with different probes and assays. (a) FA assays with UR-CG072 and UR-MK342. (b) FA assay with UR-MK342 and radioligand binding (literature data). (c) FA assay with UR-CG072 and radioligand binding (literature data). Investigated agonists are presented as orange symbols (filled orange square), antagonists as blue symbols (filled blue square). Black lines represent the linear regression between the datasets, and the dashed black lines represent the 95% confidence bands. Data shown for FA are the mean of at least three independent experiments, and the error bars represent s.e.m. Data shown for radioligand are the mean of values from articles shown in table 3, and the error bars represent s.e.m. of these data.