Table VI.

Protein levels of Hes1, PTEN, p-AKT(Thr308), p-AKT(Ser473), p-mTOR (Ser2448) and IL-17A in splenic mononuclear cells of experimental mice (each n=6).

Group	Hes1	PTEN	p-AKT (Thr308)	p-AKT (Ser473)	p-mTOR (Ser2448)	IL-17A
0 µM LY294002	1.179±0.060	0.530±0.149	1.264±0.072	1.304±0.065	1.256±0.095	1.173±0.134
10 µM LY294002	0.939±0.070a	0.788±0.097a	0.992±0.077a	1.039±0.088a	1.026±0.061a	0.951±0.074a
50 µM LY294002	0.756±0.073a,b	0.948±0.100a	0.845±0.062a,c	0.866±0.108a,c	0.857±0.109a,c	0.810±0.085a
Control	0.569±0.111a,b	1.151±0.119a,b	0.608±0.073a,b	0.450±0.084a,b	0.550±0.107a,b	0.522±0.107a,b
F-value	62.235	29.712	88.796	100.548	58.847	42.321
P-value	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

Data are presented as the means ± SD. One-way ANOVA followed by Tukey's test are used for statistical analysis.

^aP<0.01 vs. 0 µM LY294002;

^bP<0.01,

^cP<0.05 vs. 10 µM LY294002. Hes1, Hairy/enhancer of split 1; PTEN, Phosphatase and tensin homolog deleted on chromosome ten; mTOR, mammalian target of rapamycin; IL-17A, interleukin-17A.