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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Addict Biol. 2022 May;27(3):e13170. doi: 10.1111/adb.13170

Figure 6:

Figure 6:

Nicotine administration significantly elevated the breakpoint in responding for RMF infusions, regardless of context or form of punishment. (A) Following punishment of RMF intake with foot-shock, the breakpoint for RMF administration was significantly higher in nicotine-treated rats than saline-treated rats in both the unpunished and punished contexts. (B) Similarly, nicotine produced significantly higher breakpoints in RMF responding following punishment of RMF intake with histamine adulteration. Regardless of drug pretreatment, histamine punishment of RMF did not affect the breakpoint for RMF in the punished context. *s indicate significant group differences (P < 0.05).