Fig. 1.

Increase in amyloid-β plaque in the hippocampal formation of the 11-months-old 6xTg mouse model of AD. a–b Representative images of Thioflavin S stain in wild-type (WT, left) and 6xTg (right). Representative coronal sections of c In the 6xTg mice, the number of plaques was significantly increased compared with WT mice in the dorsal hippocampus, entorhinal cortex, and ventral hippocampus. d–f The dorsal hippocampus, entorhinal cortex, and ventral hippocampus from 11-month-old WT and 6xTg mice were stained with Thioflavin S. All data are given as means ± SEM (n = 3 for WT, 3 for 6xTg; One-way ANOVA, **p < 0.01, ****p < 0.0001). Scale bar, 1 mm for a-b, and 200 µm for d-f