Table 2.

Parameters of thrombin generation and levels of natural coagulation and anti-coagulant factors in the reference, arterial and venous subsample

Variable	Group
	Reference group (n = 1402) Mean ± SD	Arterial Disease group (n = 502) Mean ± SD	p-value arterial disease vs. reference	Venous Disease group (n = 195) Mean ± SD	p-value venous disease vs. reference
Lag Time [min]	4.94 ± 1.03	6.56 ± 3.71	< 0.0001	6.50 ± 3.95	< 0.0001
ETP [nM.min]	1105.0 ± 237.4	1045.0 ± 360.8	0.00056	1048.5 ± 423.3	0.070
Peak Height [nM]	118.37 ± 54.81	113.09 ± 55.36	0.067	113.50 ± 60.32	0.29
Factor II [%]	116.9 ± 17.6	108.7 ± 28.9	< 0.0001	104.8 ± 32.7	< 0.0001
Factor V [%]	116.6 ± 18.5	118.9 ± 19.9	0.024	118.4 ± 22.0	0.29
Factor VII [%]	111.1 ± 21.6	108.3 ± 31.2	0.056	107.2 ± 34.8	0.12
Factor VIII [%]	115.3 ± 33.1	136.3 ± 40.2	< 0.0001	140.1 ± 46.5	< 0.0001
Factor IX [%]	106.3 ± 14.4	110.9 ± 21.7	< 0.0001	107.4 ± 24.3	0.53
Factor X [%]	113.10 ± 19.09	105.59 ± 33.53	< 0.0001	103.87 ± 38.95	0.0013
Factor XI [%]	106.8 ± 18.2	110.2 ± 19.8	0.00090	112.6 ± 19.4	< 0.0001
Factor XII [%]	105.6 ± 24.3	102.1 ± 24.9	0.0071	105.5 ± 24.7	0.98
vWF [%]	103.1 ± 35.5	127.7 ± 45.0	< 0.0001	127.7 ± 48.3	< 0.0001
Protein C [%]	113.3 ± 17.2	111.3 ± 26.1	0.097	110.2 ± 28.3	0.13
Protein S [%]	95.1 ± 16.4	100.3 ± 24.1	< 0.0001	93.4 ± 24.7	0.34
Antithrombin [%]	102.8 ± 9.8	98.1 ± 11.9	< 0.0001	100.8 ± 10.7	0.014
TFPI Activity [U/mL]	1.57 ± 0.53	1.63 ± 0.57	0.040	1.64 ± 0.52	0.084
Fibrinogen [mg/dL]	331 ± 66	395 ± 95	< 0.0001	391 ± 95	< 0.0001

Presented are thrombin generation parameters and coagulation factors in the reference, arterial disease and venous disease subsample

Abbreviations: SD standard deviation, vWF Von Willebrand Factor, TFPI Tissue Factor Pathway Inhibitor