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. 2022 Jun 8;20:264. doi: 10.1186/s12967-022-03446-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overexpression of C2orf40 impairs the migration ability of NPC cells in vitro. A Gene set enrichment analysis (GSEA) was performed using two GEO datasets (GSE12452 and GSE53819) which compared high C2orf40 expression group and low C2orf40 expression group. The results showed the most significant enrichment of the cell migration-related genes in the high C2orf40 expression group. B The migration of HONE-1 and SUNE-1 cells stably overexpressing C2orf40 was assessed by in vitro scratch wound-healing assay. C The effects of C2orf40 overexpression on the migration and invasion abilities of SUNE-1 and HONE-1 cells were investigated via transwell migration and invasion assays. The experiments were performed in triplicate and repeated twice. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001