Table 2.
Total Cellular Uptake, Cytosolic Entry, and Endosomal Escape efficiencies of CPP12-2a
| [CPP12-2] (μM) |
[FBS] | Total Cellular Uptake (MFITMR, %) |
Cytosolic Entry (MFINF, %) |
Apparent Endosomal Escape Efficiency (γ, %) |
|---|---|---|---|---|
| CPP 12 | 10% or 1% | 100 | 100 | 100 |
| 5.0 | 10% | 98 ± 11 | 375 ± 48 | 383 ± 49 |
| 5.0 | 1% | 79 ± 13 | 85 ± 7 | 108 ± 9 |
| 2.0 | 1% | 84 ± 10 | 116 ± 5 | 138 ± 6 |
| 1.0 | 1% | 88 ± 8 | 145 ± 21 | 164 ± 24 |
| 0.5 | 1% | 94 ± 10 | 186 ± 7 | 198 ± 7 |
a
All values represent the mean ± SD of at least three independent experiments and are relative to that of CPP12 (100%).