Table 7.

12- and 24-week change in questionnaire data: appetite, food cravings, and health-related quality of life in the modified intention-to-treat population of a randomised clinical trial of Tesomet for hypopituitary patients with hypothalamic obesity. Data presented as least squares mean (95% CI) change from baseline to week 12 and 24 in the mITT population. Last observation carried forward imputation was used for missing data. Inferential tests were performed using a baseline adjusted ANCOVA model with treatment as factor and change from baseline as dependent variable.

	∆Week 0–12			∆Week 0–24
	Tesomet (n = 13)	Placebo (n = 8)	P	Tesomet (n = 13)	Placebo (n = 8)	P
Composite satiety score (mm)	12.7 (1.7; 23.8)	1.7 (−12.4; 15.7)	0.21	3.6 (−6.1; 13.4)	3.8 (8.7; 16.2)	0.99
How much do you think you can you eat?	−15.7 (−29.2; −2.2)	−10.2 (−27.5; 7.0)	0.60	−8.3 (−18.1; 1.6)	−12.5 (−25.1; 0.1)	0.59
How full do you feel?	10.1 (−2.1; 22.3)	−1.7 (−17.2; 13.8)	0.22	0.5 (−11.7; 12.6)	8.4 (−7.1; 23.9)	0.41
How hungry do you feel?	−11.7 (−26.4; 3.0)	−2.1 (−20.8; 16.6)	0.41	−5.8 (−18.9; 7.3)	10.1 (−6.6; 26.8)	0.13
How satisfied do you feel?	13.5 (1.5; 25.6)	−4.4 (−19.8; 11.1)	0.07	0.6 (−11.8; 12.9)	3.2 (−12.5; 19.0)	0.78
How comfortable do you feel?	1.5 (−10.7; 13.7)	−4.8 (−20.4; 10.8)	0.52	1.4 (−12.0; 14.8)	−0.7 (−17.8; 16.5)	0.85
Food cravings (mm)a
Like to eat something savoury	12.2 (−3.0; 27.4)	9.2 (−10.3; 28.7)	0.80	14.3 (−1.2; 29.8)	1.5 (−18.4; 21.4)	0.31
Like to eat something fatty	19.1 (11.1; 27.1)	20.5 (10.2; 30.7)	0.83	17.1 (5.8; 28.4)	8.8 (−5.6; 23.2)	0.35
Like to eat something sweet	17.9 (6.9; 28.9)	14.9 (0.8; 29.1)	0.74	12.4 (−4.7; 29.5)	16.5 (−5.5; 38.5)	0.77
Like to eat something salty	7.7 (−8.10; 23.4)	12.7 (−7.4; 32.8)	0.69	2.0 (−11.1; 15.1)	10.7 (−6.0; 27.4)	0.40
Health-related Quality of Life
Physical component score	3.1 (1.2; 4.9)	−0.3 (−2.7; 2.0)	0.03	1.2 (−2.6; 4.9)	0.6 (−4.2; 5.4)	0.84
Mental component score	−1.9 (−4.9; 1.1)	−0.3 (−4.1; 3.5)	0.50	−2.9 (−8.1; 2.3)	−1.2 (−7.8; 5.4)	0.67

^aAn increase in score represents a decrease in perceived desire.

ANCOVA, analysis of covariance; Mitt, modified intention-to-treat.