Table 2.

Incidence rate ratios (IRRs) and IRR 95% CIs of SARS-CoV-2 infections in UK Biobank men during follow-up (16 March 2020 to 31 January 2021). Estimates presented for model predictors of interest, including for quintile categories of the baseline hormone concentration (testosterone, SHBG, cFT), from Poisson regression.

Predictor	Hormone term modelled as quintile categories*
	Testosterone	SHBG	cFT
Hormone
Quintile 5 (ref)	1	1	1
Quintile 4	1.01 (0.93–1.11)	1.07 (0.97–1.17)	1.04 (0.96–1.13)
Quintile 3	0.99 (0.90–1.08)	1.02 (0.93–1.12)	0.97 (0.89–1.06)
Quintile 2	0.98 (0.90–1.08)	1.09 (0.99–1.19)	1.01 (0.92–1.10)
Quintile 1	1.04 (0.95–1.14)	1.08 (0.98–1.19)	1.02 (0.93–1.12)
Age
≤50 (ref)	1	1	1
51–60	0.62 (0.58–0.67)	0.64 (0.60–0.69)	0.62 (0.58–0.66)
>60	0.56 (0.52–0.60)	0.58 (0.54–0.63)	0.56 (0.52–0.60)
BMI
<25 (ref)	1	1	1
25–<30	1.29 (1.19–1.39)	1.28 (1.18–1.38)	1.28 (1.19–1.38)
≥30	1.63 (1.50–1.77)	1.60 (1.47–1.74)	1.62 (1.49–1.75)
Ethnicity: not White	1.64 (1.48–1.82)	1.64 (1.48–1.82)	1.66 (1.50–1.84)
Qualifications: college/university	0.68 (0.64–0.72)	0.67 (0.63–0.72)	0.67 (0.63–0.72)
Townsend Index
Quintile 1 (ref)	1	1	1
Quintile 2	1.00 (0.91–1.09)	1.00 (0.91–1.10)	1.00 (0.91–1.09)
Quintile 3	1.07 (0.98–1.17)	1.07 (0.98–1.18)	1.06 (0.97–1.16)
Quintile 4	1.16 (1.06–1.27)	1.13 (1.03–1.23)	1.15 (1.05–1.26)
Quintile 5	1.37 (1.26–1.50)	1.37 (1.25–1.49)	1.37 (1.25–1.49)

^*Quintile boundaries: testosterone: (nmol/L) Q1/2 9.0, Q2/3 10.8, Q3/4 12.5, and Q4/5 14.8 or (ng/dL) Q1/2 259, Q2/3 311, Q3/4 360, and Q4/5 427; SHBG: (nmol/L) Q1/2 25.8, Q2/3 33.1, Q3/4 40.5, and Q4/5 50.8; cFT: (pmol/L) Q1/2 171, Q2/3 201, Q3/4 230, and Q4/5 268.