. 2022 Mar 23;11(5):e210456. doi: 10.1530/EC-21-0456
This work is licensed under a Table 3.
Serum and urinary bone and mineral metabolism-related parameters, stratified by age range and by gender.
| Parameterd | Patients up to 25 years (n = 30) | Patients from 26 to 50 years (n = 52) | Patients over 51 years (n = 19) | P value group 1 vs group 2 | P value group 1 vs group 3 | P value group 2 vs group 3 | Women (n = 57) | Men (n = 44) | P value women vs men |
|---|---|---|---|---|---|---|---|---|---|
| Group 1 | Group 2 | Group 3 | |||||||
| Age at biochemical measurement (years) | 18.0 ± 4.4 | 35.9 ± 7.4 | 61.0 ± 8.1 | n.a. | n.a. | n.a. | 36.0 ± 15.6 | 34.5 ± 17.1 | Non-significant |
| Range 11–25 | Range 26–50 | Range 52–80 | |||||||
| Parathyroid hormone (1.3–7.6 pmol/L) | 8.3a ± 4.2 | 18.2a ± 20.3 | 15.3a ± 8.6 | P < 0.01 | P < 0.01 | Non-significant | 17.3a ± 19.6 | 11.4a ± 7.5 | P < 0.05 |
| Serum calcium ion (4.3–5.3 mg/dL) | 5.4a ± 0.5 | 5.5a ± 0.5 | 5.5a ± 0.6 | Non-significant | Non-significant | Non-significant | 5.5a ± 0.6 | 5.4a ± 0.5 | Non-significant |
| Total serum calcium (8.5–10.1 mg/dL) | 10.1 ± 1.0 | 10.2a ± 1.0 | 9.9 ± 0.8 | Non-significant | Non-significant | Non-significant | 10.1 ± 1.1 | 10.1 ± 0.8 | Non-significant |
| Serum phosphate (2.5–4.9 mg/dL) | 3.1 ± 1.1 | 2.6 ± 0.7 | 2.6 ± 0.5 | P < 0.05 | P < 0.05 | Non-significant | 2.7 ± 0.8 | 2.8 ± 0.9 | Non-significant |
| 25-hydroxy-vitamin D (30–100 ng/mL) | 25.6b ± 9.6 | 20.1b ± 11.0 | 25.1b ± 12.1 | P < 0.05 | Non-significant | Non-significant | 22.3b ± 10.7 | 23.4b ± 11.6 | Non-significant |
| Bone alkaline phosphatase (Men: 7–20µg/L; pre-menopausal women: 4–14.3 µg/L; post-menopausal women: 6–22.5 µg/L)c | 40.9b ± 31.3 | 21.9b ± 11.4 | 19.8 ± 8.7 | P < 0.01 | P < 0.01 | Non-significant | 23.3a ± 15.1 | 31.5a ± 25.9 | Non-significant |
| Urinary calcium (42–353 mg/24 h) | 220.1 ± 159.4 | 315.2 ± 164.3 | 254.8 ± 148.8 | P < 0.05 | Non-significant | Non-significant | 253.6 ± 159.0 | 299.9 ± 166.6 | Non-significant |
| Urinary phosphate (400–1300 mg/24 h) | 754.6 ± 250.3 | 744.6 ± 288.7 | 742.7 ± 265.7 | Non-significant | Non-significant | Non-significant | 665.3 ± 255.5 | 856.3 ± 258.6 | P < 0.01 |
| Urinary deoxypyridinoline (3.0–5.4 mnol/mmol creatinine) | 11.4a ± 6.3 | 6.8a ± 2.5 | 6.2a ± 2.6 | P < 0.01 | P < 0.01 | Non-significant | 8.3a ± 3.7 | 7.6a ± 5.4 | Non-significant |
aA parameter value higher than the normal range; bA parameter value less than the normal range; cReference values for bone alkaline phosphatase from our hospital analysis laboratory are referred to adult men and adult women; dReferral normal values for bone and mineral metabolism biochemical parameters are indicated within brackets.
n.a., not applicable.
Parameters presenting a significant difference between different groups of patients are highlighted in bold, with P < 0.05 indicating a statistical significance of 95%, and P < 0.09 indicating a statistical significance of 99%.