Table 2.

Serum levels of LEAP2, ghrelin, ghrelin/LEAP2 ratio in healthy adults and T2D subjects, and in male and female groups (normal n  = 27: 19M+8F; T2DM n  = 29: 21M+8F). Data are presented as median (IQR) for LEAP2. Ghrelin and ghrelin/LEAP2 are presented as mean (95% CI).

	Normal			T2D			P value
	All	Male	Female	All	Male	Female
LEAP2 (ng/mL)	1.61 (1.35; 2.23)	1.59 (1.32; 2.13)	1.83 (1.43; 2.58)	3.55 (1.64; 5.90)	3.37 (1.64; 5.90)	3.40 (1.28; 6.08)	0.0080
Ghrelin (ng/mL)	50.88 (41.57; 60.20)	47.54 (37.02; 58.05)	58.83 (36.17; 81.49)	37.46 (31.74; 43.17)	34.68 (29.57; 39.79)	44.75 (26.85; 62.65)	0.0296
Ghrelin/LEAP2	30.22 (23.14; 37.31)	29.96 (21.68; 38.24)	30.85 (13.47; 48.23)	14.60 (10.63; 18.57)	18.41 (12.54; 24.28)	17.05 (6.79; 27.30)	0.0005

Bold values are statistically significant (P < 0.05).

LEAP2, liver-expressed antimicrobial peptide 2; T2D, type 2 diabetes.