TABLE 1.
Frequency of hypertension in patients with hereditary thrombotic thrombocytopenic purpura (TTP). Panel A: A systematic review of published case reports. Panel B: Analysis of patients enrolled in the International Hereditary TTP Registry
| Panel A: Systematic review of published case reports | ||
|---|---|---|
| Patients | Articles | Description |
| 132 | 51 | Blood pressure or hypertension not reported |
| 48 (27%) | 29 | Blood pressure or hypertension reported a |
| Blood pressure or hypertension reported (29 articles) | ||
| 14 (29%) | 5 | Blood pressure reported as normal |
| 15 (31%) | 11 | Hypertension reported, attributed to pregnancy |
| 19 (40%) | 13 | Hypertension reported, not associated with pregnancy. Age of onset was reported for 12 patients: range, 1.6‐39 years; median, 8 years |
| Panel B: International Hereditary TTP Registry | ||
|---|---|---|
| Patients | Hypertension | Description |
| 139 | 40 (29%) b | Age: range, 8‐88 years; median, 43 years. Age of onset of hypertension was not included in the registry database. |
a
Blood pressure was often reported only as normal or only as hypertension being present, without actual measurement data or requirement for antihypertensive treatment. One article reported patients without hypertension and also patients with hypertension. The 19 patients with hypertension not associated with pregnancy are individually described in the Table S1.
b
Hypertension was identified by the patient's report of taking prescribed antihypertensive medication.