. 2021 Jun 22;2(3):413–420. doi: 10.1002/jha2.224

TABLE 1A.

Comparison of peg‐asparaginase and steroid dosing in the standard CALGB 10403 regimen and the reduced‐dose regimen

CALGB 10403 dosing for PEG‐ASP and corticosteroids
Agent	Standard dose	Reduced dose
PEG‐ASP (Throughout treatment course)	2500 IU/m² IV	1000 IU/m² IV ^*Can further reduce for Age ≥ 50 years or comorbidities of NASH, diabetes, or obesity
Corticosteroids (During Induction)	Prednisone 60 mg/m2/day PO or IV on days 1–28 ^*Equivalent to dexamethasone 252 mg/m²/induction course	Dexamethasone 10 mg/m² PO or IV on days 1–7 and 15–21 ^*Can further reduce to 10 mg/m² on Days 1–7 alone

CALGB 10403 dosing for PEG‐ASP and corticosteroids

Agent

Standard dose

Reduced dose

PEG‐ASP (Throughout treatment course)

2500 IU/m² IV

1000 IU/m² IV

^*Can further reduce for Age ≥ 50 years or comorbidities of NASH, diabetes, or obesity

Corticosteroids (During Induction)

Prednisone 60 mg/m2/day PO or IV on days 1–28

^*Equivalent to dexamethasone 252 mg/m²/induction course

Dexamethasone 10 mg/m² PO or IV on days 1–7 and 15–21

^*Can further reduce to 10 mg/m² on Days 1–7 alone

Abbreviations: IU, international units; IV, intravenously; PEG‐ASP, peg‐asparaginase; PO, orally.