Figure 3. scRNA-seq analysis of T + E and str^AR− T + E prostate.

(A) t-SNE plots showing various cell populations (identifiable by markers listed on the right) in the T + E and str^AR− T + E prostate.

(B) UMAP showing color-coded cell clusters of integrated samples using scVI tools.

(C) UMAP showing alignment of cell types between the T + E and the str^AR− T + E samples.

(D) Volcano plot showing up- and downregulated genes in str^AR− T + E versus T + E.

(E–H) GSEA comparing differentially expressed genes in secretory luminal cells of str^AR− T + E versus T + E against GO pathways and published gene signatures.