TABLE 1.
Hematologic data for proband, son, and daughter. a
| Age | Hgb (13–17 g/dl) | MCV (81–96 fl) | MCHC (32–36 g/dl) | RDW (11.5–14.2%) | Retic count (0.4–2%) | Platelet count (150–350 K/μl) | Total bilirubin (0–1.2 mg/dl) | Ferritin F (13–150 ng/ml) M (30–400 ng/ml) | LDH (100—250 u/L) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Proband b , c | 61 | 10.5 (±0.3) | 106.5 (±1.3) | 34.1 (±0.5) | 15 (±0.4) | 12.6 (±2) | 532.2 (±32.9) | 6 (±0.9) (Bili D < 0.1 ‐ 0.6) | 503.2 (±113.2) | 438.5 (±153) |
| Daughter | 39 | 11.1 (±0.7) | 99.9 (±2.9) | 33.9 (±1) | 16.1 (±0.3) | 6.7 (±1.5) | 192.3 (±49.4) | 2.3 (±0.5) (Bili D < 0.1‐ 0.3) | 222.5 (±84.5) | 301 (±148) |
| Son b , d | 34 | 9.3 (±0.4) | 98.8 (±3.1) | 32.9 (±0.7) | 21.2 (±0.6) | >22 | 837 (±64.7) | 5.7 (±0.7) (Bili D < 0.1 – 0.4) | 1061.9 (±53.5) | 483.5 (±233.5) |
a
Means calculated from at least 25 measurements, except for Ferritin and LDH which are means of at least four values.
b
Splenectomized.
c
Post‐menopausal. Prior to menopause, her average ferritin was 369 ng/ml (±109.8).
d
Ferritin values prior to iron chelation therapy.