FIGURE 2.

BCMA expression and TNB‐383B anti‐PC activity ex vivo. A, B‐cell maturation antigen expression among the 10 bone marrow aspirates tested at baseline following BMMC isolation. Frequency of BCMA+ (%) and mean fluorescence intensity of BCMA+ PC (MFI) were determined by flow cytometry. B, Median BCMA+ PC counts (25%) was used as a cutoff value to test the effect of target expression on TNB‐383B‐induced PC lysis, viability (7‐AAD⁻) and death by apoptosis (Annexin‐V⁺) by factorial ANOVA. C, Alterations on BCMA expression by PC (frequency of BCMA⁺ PC and BCMA MFI) among the 10 BMMC preparations tested following 24 ± 2 h ex vivo treatment with 1 μg/mL TNB‐383B