. 2021 Jul 19;2(3):366–374. doi: 10.1002/jha2.262

TABLE 1.

Comparing of average hematological parameters in carrier of beta thalassemia, sickle cell trait, and healthy individuals with and without alpha triplication

β genotype	α genotype	n	Gender female/male	Age mean ± SD	MCV (fL) mean ± SD	MCH (pg) mean ± SD	Hb (g/dl) mean ± SD	RBC (10¹²/L) mean ± SD	Hb A (%) mean ± SD	Hb A2 (%) Mean ± SD	Hb F (%) Mean ± SD
wt/wt	ααα^{anti 3.7}/αα	18	8/10	26 ± 4.72	81.47 ± 5.76	26.05 ± 1.26	13.5 ± 1.2	5.13 ± 0.46	96.97 ± 0.46	2.58 ± 0.27	0.5 ± 0.23
p‐value					0.79	0.75	0.88	0.83	0.63	0.76	0.9
CD36/37‐T/wt	αα/αα	265	137/128	26.7 ± 5.2	62.15 ± 3.36	19.03 ± 1.2	11.36 ± 1.3	6.08 ± 0.90	93.73 ± 1.24	5.25 ± 0.87	0.84 ± 0.73
CD36/37‐T/wt	ααα^{anti 3.7}/αα	17	9/8	27 ± 9.4	59.64 ± 4.8	18.45 ± 1.03	10.88 ± 1.21	5.6 ± 0.74	94.55 ± 0.40	5.07 ± 0.77	0.47 ± 0.22
p‐value					0.022	0.10	0.29	0.072	0.208	0.54	0.33
IVSII‐I(G‐A)/ wt	αα/αα	239	135/104	25.65 ± 7.0	63.32 ± 3.56	19.52 ± 1.36	11.37 ± 1.46	5.84 ± 0.82	94.02 ± 1.30	4.71 ± 0.95	1.46 ± 1.02
IVSII‐I(G‐A)/ wt	ααα^{anti 3.7}/αα	10	5/5	27.7 ± 4.41	61.05 ± 2.01	19.58 ± 1.48	10.98 ± 1.56	5.54 ± 0.75	93.77 ± 3.05	4.97 ± 0.37	0.9
p‐value					0.088	0.91	0.52	0.35	0.78	0.59	?
CD44(‐C)/ wt	αα/αα	112	50/62	24.7 ± 3.2	62.79 ± 2.85	19.17 ± 0.79	11.46 ± 1.42	6.00 ± 0.66	94.38 ± 0.62	4.92 ± 0.53	0.57 ± 0.23
CD44(‐C)/ wt	ααα^{anti 3.7}/αα	5	2/3	30.3 ± 3.3	58.50 ± 0.71	18.00 ± 2.82	10.40 ± 0.14	5.90 ± 0.28	94.45 ± 0.21	5.40 ± 0.28	?
p‐value					0.062	0.192	0.328	0.835	0.894	0.265	?
5′UTR+20(C‐T)/ wt	αα/αα	160	52/108	27.1 ± 3.35	61.79 ± 3.10	18.67 ± 0.87	12.05 ± 0.91	6.46 ± 0.57	94.15 ± 0.77	5.26 ± 0.71	0.52 ± 0.25
5′UTR+20(C‐T)/ wt	ααα^{anti 3.7}/αα	5	2/3	24.0 ± 5.5	66.50 ± 0.28	18.40 ± 0.56	11.3 ± 0.141	6.03 ± 0.05	93.45 ± 0.64	5.15 ± 0.21	?
p‐value					0.066	0.687	0.292	0.335	0.294	0.845	?
CD82‐83(−G)/ wt	αα/αα	123	62/61	29.0 ± 8.1	62.92 ± 2.9	19.66 ± 2.15	11.29 ± 1.52	5.78 ± 1.04	93.74 ± 1.16	5.00 ± 0.66	1.12 ± 0.82
CD82‐83(−G)/ wt	ααα^{anti 3.7}/αα	4	2/2	26.0 ± 8.5	61.00 ± 0.14	18.95 ± 0.63	11.7 ± 1.70	?	?	?	?
p‐value					0.382	0.650	0.724	?	?	?	?
CD8(‐AA)/ wt	αα/αα	175	120/55	29.4 ± 8.8	64.06 ± 2.3	19.87 ± 0.95	10.40 ± 0.95	5.37 ± 0.59	93.73 ± 0.59	4.98 ± 0.77	1.14 ± 0.66
CD8(‐AA)/ wt	ααα^{anti 3.7}/αα	3	3/0	22.3 ± 5.1	62.45 ± 0.77	20.80 ± 0.28	10.2 ± 1.13	4.68 ± 0.17	94.5 ± 0.70	4.85 ± 0.820	?
p‐value					0.359	0.207	0.780	0.132	0.150	0.820
−28(A‐C)/ wt	αα/αα	125	62/63	25.4 ± 8.7	70.73 ± 3.02	22.33 ± 1.18	12.72 ± 1.08	5.71 ± 0.4	94.27 ± 0.57	4.91 ± 0.76	0.67 ± 0.32
−28(A‐C)/ wt	ααα^{anti 3.7}/αα	2	1/1	23 ± 0.7	72.85 ± 0.63	22.7 ± 1.41	12.50 ± 0.70	4.8 ± 0.28	?	?	?
p‐value					0.338	0.679	0.776	0.844
IVSI‐6(T‐C)/ wt	αα/αα	126	59/67	27.14 ± 6.8	70.77 ± 4.71	21.83 ± 1.79	12.68 ± 1.55	5.81 ± 0.55	95.99 ± 0.73	3.58 ± 0.74	0.61 ± 0.31
IVSI‐6(T‐C)/ wt	ααα^{anti 3.7}/αα	2	1/1	25.5 ± 2.1	72.20 ± 0.28	22.6 ± 0.42	12.0 ± 0.3	5.24 ± 0.19	95.30 ± 0.14	3.85 ± 0.07	0.60 ± 0.14
p‐value					0.676	0.558	0.638	0.158	0.206	0.62	0.978
Fr8‐9(+G)/ wt	αα/αα	127	61/66	26.0 ± 5.2	62.82 ± 2.98	19.13 ± 1.33	11.36 ± 1.28	5.97 ± 0.69	94.09 ± 0.96	5.13 ± 0.86	0.8 ± 0.53
Fr8‐9(+G)/ wt	ααα^{anti 3.7}/αα	3	1/2	23.5 ± 2.1	59.0 ± 1.41	18.5 ± 0.71	10.25 ± 1.06	5.50 ± 0.71	94.0 ± 0.42	5.5 ± 0.42	0.5 ± 0.0
p‐value					0.088	0.512	0.249	0.355	0.90	0.569	0.461
CD15(TGG‐GA)/ wt	αα/αα	125	60/65	26 ± 5.7	62.67 ± 2.30	19.25 ± 0.95	12.07 ± 1.31	6.33 ± 0.73	94.03 ± 0.68	5.05 ± 0.97	0.62 ± 0.42
CD15(TGG‐GA)/ wt	ααα^{anti 3.7}/αα	2	1/1	24 ± 1.41	60.75 ± 4.45	18.43 ± 1.03	10.9 ± 1.55	5.90 ± 0.51	94.25 ± 1.48	4.95 ± 0.92	0.45 ± 0.07
p‐value					0.291	0.255	0.245	0.422	0.724	0.890	0.579
Indian deletion/ wt	αα/αα	10	5/5	29 ± 7.7	58.94 ± 2.60	18.72 ± 1.23	10.97 ± 2.17	5.867 ± 1.09	96.53 ± 1.34	2.92 ± 0.64	0.66 ± 0.47
Indian deletion/ wt	ααα^{anti 3.7}/αα	3	3/0	25 ± 2	59.56 ± 2.97	17.9 ± 0.17	12.15 ± 0.21	5.39 ± 0.11	94.9 ± 0.14	3.3 ± 0.14	1.7 ± 0141
p‐value					0.727	0.290	0.480	0.486	0.20	0.467	0.064
−101(C > T)/ wt	αα/αα	64	34/30	26 ± 5.4	79.48 ± 4.5	26.2 ± 1.9	14.0 ± 1.76	5.36 ± 0.64	95.82 ± 0.9	3.4 ± 0.5	0.86 ± 0.62
−101(C > T)/ wt	ααα^{anti 3.7}/αα	3	1/2	24 ± 2.0	77.2 ± 0.32	26.3 ± 1.2	15.6 ± 0.97	5.93 ± 0.2	95.7 ± 0.5	3.5 ± 0.25	0.5 ± 0.2
p‐value					0.45	0.92	0.14	0.15	0.9	0.74	0.58
IVSI‐110(G > A)/ wt	αα/αα	180	93/87	27.2 ± 6.5	64.8 ± 5.3	20.6 ± 1.7	12.01 ± 1.28	5.91 ± 0.65	94.5 ± 1.9	4.5 ± 0.6	0.96 ± 0.81
IVSI‐110(G > A)/ wt	ααα^{anti 3.7}/αα	3	2/1	25.6 ± 3.2	66.9 ± 10.9	21.7 ± 4.9	12.1 ± 2.4	5.6 ± 0.25	93.3 ± 2.7	4.3 ± 1.02	2.3 ± 1.7
p‐value					0.52	0.33	0.94	0.41	0.31	0.67	0.019
IVSI‐I(G > A)/ wt	αα/αα	111	60/51	28.4 ± 5.2	63.02 ± 3.73	19.21 ± 1.37	11.47 ± 1.20	5.63 ± 0.73	94.38 ± 2.90	4.46 ± 0.9	1.28 ± 0.99
IVSI‐I(G > A)/ wt	ααα^{anti 3.7}/αα	1	1/0	?	63	19.4	10.6	4.6	?	?	?
p‐value					?	?	?	?	?	?	?
CD5(‐CT)/ wt	αα/αα	43	21/19	26.1 ± 4.7	63.29 ± 3.80	19.42 ± 1.09	11.59 ± 1.30	6.03 ± 0.7	94.58 ± 0.88	5.03 ± 0.71	0.76 ± 0.60
CD5(‐CT)/ wt	ααα^{anti 3.7}/αα	1	1/0	28	63.3	18.6	10.2	5.7	?	?	?
p‐value					?	?	?	?	?	?	?
IVSI‐5(G > C)/ wt	αα/αα	144	78/66	27 ± 5.4	65.2 ± 4.7	20.1 ± 1.9	11.9 ± 1.4	5.8 ± 0.6	94.9 ± 0.7	4.2 ± 0.6	0.76 ± 0.5
IVSI‐5(G > C)/ wt	ααα^{anti 3.7}/αα	1	0/1	26	67	21.5	9.0	5.71	?	?	?
p‐value					?	?	?	?	?	?	?
Initiation CD(T > C)/wt	αα/αα	40	16/24	26 ± 3.1	73.74 ± 8.8	23.07 ± 3.3	12.72 ± 1.29	5.56 ± 0.7	96.35 ± 1.46	3.15 ± 1.3	0.5 ± 0.4
Initiation CD(T > C)/wt	ααα^{anti 3.7}/αα	1	0/1	26	54.6	17.4	12.6	7.25	?	5.8	?
p‐value					?	?	?	?	?	?	?
CD39 (C > T)/ wt	αα/αα	63	32/31	28.4 ± 6.8	62.7 ± 6.74	19.65 ± 1.3	11.42 ± 1.28	5.85 ± 0.69	94.4 ± 1.26	4.63 ± 1.2	0.86 ± 0.72
CD39 (C > T)/ wt	ααα^{anti 3.7}/αα	1	0/1	22	61.6	20.1	11.5	5.73	93.3	6.1	0.6
p‐value					?	?	?	?	?	?	?
Hb S/ wt	αα/αα	400	220/180	25.85 ± 4.5	83.73 ± 4.32	28.22 ± 1.97	13.78 ± 1.71	4.86 ± 0.56	57.11 ± 4.83	2.65 ± 0.81	0.61 ± 0.53
Hb S/ wt	ααα^{anti 3.7}/αα	4	1/3	24.3 ± 10.0	85.95 ± 6.5	27.5 ± 1.34	13.96 ± 0.86	5.17 ± 0.11	56.72 ± 2.27	3.12 ± 0.38	0.27 ± 0.38
p‐value					0.355	0.47	0.854	0.280	0.874	0.261	0.276