TABLE 3.
Mean FACT‐Leu scores at baseline and at 6 and 12 months by baseline FACT‐Leu cluster in patients with CLL receiving LOT1
| FACT‐Leu subscale | Inferior baseline FACT‐Leu N = 77 | Intermediate baseline FACT‐Leu N = 199 | Superior baseline FACT‐Leu N = 246 | Overall N = 522 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | |
| Physical | 17.3 | 20.4 | 21.0 | 21.6 | 22.6 | 23.0 | 25.8 | 25.5 | 25.5 | 23.0 | 23.7 | 23.9 |
| Social | 20.8 | 20.4 | 21.6 | 23.4 | 23.1 | 22.9 | 25·9 | 24·9 | 24·9 | 24·2 | 23·6 | 23·6 |
| Functional | 12·3 | 15·3 | 16·5 | 18·3 | 19·4 | 19·3 | 24·2 | 23·5 | 23·3 | 20·2 | 20·7 | 20·7 |
| Emotional* | 17·6 | 19·5 | 20·3 | 21·3 | 21·8 | 21·8 | 24·1 | 24·2 | 24·3 | 22·1 | 22·6 | 22·8 |
| Additional Concerns* | 11·6 | 16·5 | 16·5 | 16·2 | 18·3 | 18·7 | 21·9 | 22·5 | 22·2 | 18·2 | 20·0 | 20·0 |
Abbreviations: CLL, chronic lymphocytic leukemia; FACT‐Leu, Functional Assessment of Cancer Therapy–Leukemia; HRQoL, health‐related quality of life; LOT1, first‐line therapy.
*In order to present all scores on the spider plots, scores were rescaled to match the other categories (0‐28). Emotional subscale was rescaled using the following equation: floor(Emotional Well‐Being score × 28/24). Additional Concerns subscale was rescaled using the following equation: floor([Additional Concerns score − 14] × 28/54). Higher scores reflect better HRQoL.